Molecular glues can stabilize protein-protein interactions (PPIs) and have emerged as a promising class of therapeutics for many “undruggable” proteins. Deep-learning approaches show enormous potential for revolutionizing structure-based drug design. However, all deep learning methods require a large training dataset containing information on the binding pocket. Such information is often unavailable for molecular glues. This […]
Read the full article at: https://research.wisc.edu/a-novel-deep-learning-platform-in-design-molecular-glues-that-stabilize-protein-protein-interactions/